The story is told in three main arcs, with most of it occurring during a 24-month period beginning and ending at Thanksgiving parties hosted by Hannah (Mia Farrow) and her husband, Elliot (Michael Caine). Hannah serves as the stalwart hub of the narrative; most of the events of the film connect to her.

• Hannah and Her Sisters
• Lloyd Nolan
• Woody Allen
• Michael Caine
• Mia Farrow
• Carrie Fisher
• Barbara Hershey
• Maureen OSullivan
• Daniel Stern
• Max von Sydow
• Dianne Wiest